Neurologically Favorable Survival After In-Hospital Cardiac Arrest

December 13, 2013

A recent article in the Journal of the American Medical Association entitled "Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial" describes a double blind, randomized study performed in Greece regarding cardiac arrest survival to hospital discharge. 

Between September 1, 2008 and October 1, 2010, 268 cardiac arrest patients were treated with either vasopressin plus epinephrine or saline placebo plus epinephrine during the first five CPR cycles after randomization. The first group also received methylprednisolone during the first CPR cycle, while the second group received a saline placebo.

The study demonstrated that patients receiving vasopressin and methylprednisolone during cardiac arrest had a 13% higher neurological recovery rate than those patients only receiving epinephrine. This study has the potential to change future protocols and may allow for greater increases in neurological function in patients after ROSC during cardiac arrest.

Speakers: David Page, MS, NREMT-PAlexander Trembley, NREMT-PKeith Wesley, MD, FACEPPeter Tanghe, MD

Original study: "Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial," by Spyros D. Mentzelopoulos, MD, PhD; Sotirios Malachias, MD; Christos Chamos, MD; Demetrios Konstantopoulos, MD; Theodora Ntaidou, MD; Androula Papastylianou, MD, PhD; Iosifinia Kolliantzaki, MD; Maria Theodoridi, MD; Helen Ischaki, MD, PhD; Demosthenes Makris, MD, PhD; Epaminondas Zakynthinos, MD, PhD; Elias Zintzaras, MD, PhD; Sotirios Sourlas, MD; Stavros Aloizos, MD; Spyros G. Zakynthinos, MD, PhD.